苯巴比妥、双歧杆菌四联活菌片和蒙脱石散联合佐治新生儿高胆红素血症疗效观察

目的探讨一种有效、安全、简便的治疗新生儿高胆红素血症的方法。方法将120例患儿随机分成两组，对照组给予蓝光照射等常规治疗，治疗组在常规治疗基础上加用苯巴比妥、双歧杆菌、蒙脱石散三药口服，比较两组治疗有效率、治疗后胆红素水平，以及不良反应的发生率。结果有效率：治疗组为96．7％，对照组为80％，差异有统计学意义，治疗组日均胆红素下降值为（58．91±22．40）μmol／L，对照组为（38．61±21．63）μmol／L，差异有统计学意义，对照组有腹泻、发热、皮疹等较多不良反应，治疗组除个别嗜睡、便秘无明显不良反应。结论苯巴比妥、双歧杆菌四联活菌片、蒙脱石散三药联合应用治疗新生儿高胆红素血症疗效确切，经济方便。

CURATIVE EFFECT OBSERVATION OF PHENOBARBITAL COMBINED WITH TETRALOGY OF VIABLE BIFIDOBACTERIUM TABLETS AND MONTMORILLONITE POWDER ON NEONATAL HYPERBILIRUBINEMIA

Objective： To explore a effective, safe and convenient treatment on neonatal hyperbilirubinemia. Methods： 120 neonates with hyperbilirubinemia were randomly divided into two groups as a control group and a treatment group. Blue light irradiation and other conventional therapy for the control group, an additional treatment of taking phenobarbital, tetralogy of viable bifidobacterium tablets, and montmorillonite powder on the basis of conventional treatment for the treatment group were done. The effective rates, bilirubin levels posttreatment adverse reaction rates between two groups were compared. Results： There was statistically significant difference in effective rates between the two groups, 96.7% for the treatment group and 80% for the control group respectively. The drop-out values of the average daily bilirubin were （58.91 ± 22.40） umol/L for the treatment group and （38.61±21.63） umol/L for the control group respectively, also with statistically significant difference. There were many adverse reactions like diarrhea, fever, tetter etc. in control group, while not obvious adverse reactions except several drowsiness and constipation in treatment group. Conclusion： The combined application of phenobarbital, tetralogy of viable bifidobacterium tablets, and montmorillonite powder could be effective, economical and convenient on neonatal hyperbilirubinemia