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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index |
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| Authors: | Speliotes Elizabeth K Willer Cristen J Berndt Sonja I Monda Keri L Thorleifsson Gudmar Jackson Anne U Lango Allen Hana Lindgren Cecilia M Luan Jian'an Mägi Reedik Randall Joshua C Vedantam Sailaja Winkler Thomas W Qi Lu Workalemahu Tsegaselassie Heid Iris M Steinthorsdottir Valgerdur Stringham Heather M Weedon Michael N Wheeler Eleanor Wood Andrew R Ferreira Teresa Weyant Robert J Segrè Ayellet V Estrada Karol Liang Liming Nemesh James Park Ju-Hyun Gustafsson Stefan Kilpeläinen Tuomas O Yang Jian Bouatia-Naji Nabila Esko Tõnu Feitosa Mary F Kutalik Zoltán Mangino Massimo Raychaudhuri Soumya |
| Institution: | Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. |
| Abstract: | Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ～ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10??), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation. |
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