Single-chain polymer nanoparticles |
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Authors: | Miren?Karmele?Aiertza Ibon?Odriozola Germán?Caba?ero Hans-Jürgen?Grande Email author" target="_blank">Iraida?LoinazEmail author |
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Institution: | 1.New Materials Department, Fundación CIDETEC, Parque Tecnológico de San Sebastián,Donostia-San Sebastián,Spain |
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Abstract: | The synthesis of polymer nanoparticles (NPs) with controlled characteristics has become an appealing research topic lately.
Nanomedicine, and especially drug delivery and imaging, are fields that require particles of a controlled size and with a
tailored arrangement of functional groups. Intramolecular cross-linking or collapse of single polymer chains has emerged as
an efficient alternative for the synthesis of well-defined polymer NPs. This technique allows the generation of 1.5–20 nm
particles with a wide variety of chemical compositions and functionalities. This review begins by gathering synthetic strategies
described in the literature and groups them into four main synthetic methods: homo-functional collapse, hetero-functional
collapse, crosslinker-mediated collapse, and one-block collapse of diblock or triblock copolymers. Afterwards, the main characterization
techniques and physical properties of single-chain polymer NPs (SCPNs) are exposed. Finally, several applications in nanomedicine
are mentioned followed by some future perspectives. |
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