| 分辨学习中海马CA1区不同传入通路的突触传递效能变化 |
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| 引用本文： | 肖鹏,冯肇能,刘文晓.分辨学习中海马CA1区不同传入通路的突触传递效能变化[J].华南师范大学学报(自然科学版),2000(1):104-108. |
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| 作者姓名： | 肖鹏 冯肇能 刘文晓 |
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| 作者单位： | 华南师范大学生物学系!广州 510631 |
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| 基金项目： | 国家自然科学基金!（39300039） |
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| 摘 要： | 采用电生理学与行为学的结合方法，通过慢性埋植微电极技术，观察到大鼠在明暗分辨学习的建立过程中，海马ＣＡ１区不同传入突触上（Ｓｃｈａｆｆｅｒ－ＣＡ１与Ｐｅｒｆｏｒａｎｔ Ｐａｔｈ－ＣＡ１）均同步产生传递效能的长时程增强（ＬＴＰ）变化，在产生这一习得性ＬＴＰ的幅度上，ＰＰ－ＣＡ１大于Ｓｃｈ－ＣＡ１，而对照的假性训练动物却均未见到有这种变化，差异显著（Ｐ〈０．０１）。结果表明ＣＡ１区的不同传入通路在参与
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| 关 键 词： | 分辨学习 长时程增强 海马 突触传递效能 |
| 修稿时间： | 1999-07-01 |
CHANGES OF SYNAPTIC TRANSMISSION EFFICACY AT DIFFERENT TO CA_1 AREA OF HIPPOCAMPUS DURING DISCRIMINATION LEARNING |
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| XIAO Peng, FENG Zhaoneng, LIU Wenxiao, OU Yingqi, XU Shitong.CHANGES OF SYNAPTIC TRANSMISSION EFFICACY AT DIFFERENT TO CA_1 AREA OF HIPPOCAMPUS DURING DISCRIMINATION LEARNING[J].Journal of South China Normal University(Natural Science Edition),2000(1):104-108. |
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| Authors: | XIAO Peng FENG Zhaoneng LIU Wenxiao OU Yingqi XU Shitong |
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| Abstract: | Electrophysiological and behavioral studies were conducted to investigate the changes of synaptic effcacy of the two inputs into CA_1 area (Schaffer - CA_1 and Perforant path - CA_1 ) during discrimination learning in rats. The results showed that the learning - dependent long - term potentiation (LTP) in both inputs developed synchronously following learning, while pseudotraining rats did not show such changes. These results suggest that the changes of synaptic efficacy of different inputs of hippocampus CA_1 area coordinated during discrimination learning. |
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| Keywords: | discrimination learning long - term potentiation hippocampus Sch - CA_1 PP - CA_1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
