中成药药用胶囊中4种有毒金属元素测定方法

对中成药药用胶囊中铬、镉、砷、铅4种有毒金属元素的含量进行了测定.利用V（HNO3）∶V（HF）∶V（H2O2）=4∶1∶1的混合酸体系,消解含有Ti、Si氧化物的药用胶囊.采用石墨炉原子吸收光谱法（GF-AAS）和电感耦合等离子体发射光谱法（ICP-OES）对样品中的4种有毒金属元素进行了测定.结果表明：4种中成药药用胶囊中铬的含量均符合2010年版《中国药典》（二部）明胶空心胶囊标准要求,镉、砷、铅3种元素含量也均符合我国《药用植物及制剂进出口绿色行业标准》规定.说明两种方法均可以满足中成药药用胶囊中铬、镉、砷、铅4种金属元素的检测.对于高含量的样品,ICP-OES法简便、快捷、高效;而对于低含量的样品,GF-AAS法加标回收率更好,准确度更高.

Determination of 4 Toxic Metallic Elements in Medical Capsules of Chinese Traditional Medicines

To determine the content of chromium, cadmium, arsenic and lead toxic metallic elements in medical capsules of chinese traditional medicines. The compounds containing titanium oxide or silicon oxide were completely decomposed effectually by V（HNOa） ：V（H202） ： V（HF）=4 ： 1 ： 1 mixed acid digested system. The four toxic elements in samples were determined by graphite furnace atomic absorption spectrome- try （GF-AAS） and inductively coupled plasma optical emission spectrometr （ICP-OES）, respectively. The chromium content of four chinese traditional medicines were up to the standard of the ＂hollow gelatin capsules＇in China Pharmacopoeia（ Ⅱ, 2010Ed）. The content of Cd, As and Pb were in line with China＇s ＂medicinal plants and formulations import and export of green industry standards＂. The results showed that the two detection methods were applicable to the determination of Cr, Cd, As and Pb in medical cap- sules of chinese traditional medicines. The method of ICP-OES is more simple, fast and efficient for the samples of higher-contents. But the method of GF-AAS is better recov- ery and accuracy for the low content of samples.