| 手性色谱固定相拆分手性药物坦索罗辛 |
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| 引用本文： | 薛洪宝,胡进勇,钟延霞,刘庆彬.手性色谱固定相拆分手性药物坦索罗辛[J].河北师范大学学报(自然科学版),2008,32(1):81-84. |
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| 作者姓名： | 薛洪宝 胡进勇 钟延霞 刘庆彬 |
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| 作者单位： | 1. 河北师范大学,化学化工研究所,河北,石家庄,050091;蚌埠医学院,化学教研室,安徽,蚌埠,233000
2. 河北师范大学,化学化工研究所,河北,石家庄,050091 |
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| 摘 要： | 采用天然手性中心多糖类手性反相色谱固定相填料,高氯酸钠水溶液和乙腈为流动相,在不同的流动相比例下拆分了手性药物坦索罗辛.研究了该化合物在不同条件下色谱参数变化的规律,包括保留时间、分离度、塔板数、半峰宽度、对称度等.得到了较好的拆分该手性化合物的色谱条件.
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| 关 键 词： | 手性固定相 手性分离 坦索罗辛 |
| 文章编号： | 1000-5854（2008）01-0081-04 |
| 收稿时间： | 2006-11-14 |
| 修稿时间： | 2007-07-06 |
Chiral Stationary Phase for Resolution of Tamsulosin Hydrochloride |
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| XUE Hong-bao,HU Jin-yong,ZHONG Yan-xia,LIU Qing-bin.Chiral Stationary Phase for Resolution of Tamsulosin Hydrochloride[J].Journal of Hebei Normal University,2008,32(1):81-84. |
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| Authors: | XUE Hong-bao HU Jin-yong ZHONG Yan-xia LIU Qing-bin |
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| Abstract: | Using a natural polysaccharide-derived loading material as chiral stationary phase,sodium perchlorate solution and acetonitrile as mobile phase, racemic tamsulosin hydrochloride was separated by adjusting different proportion of mobile phase. The HPLC parameters of this compound, including retention time, degree of separation,number of plates, half peak breadth, degree of symmetry was studied in the different condition. The excellent condition of separation racemic tamsulosin hydrochloride was obtained. |
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| Keywords: | chiral stationary phase chiral separation tamsulosin |
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