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Corticosteroid effects on cholinergic enzymes in ethanol-treated fetal brain cell cultures |
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| Authors: | J W Brown A D Okonmah K F A Soliman A Carballeira L M Fishman |
| Institution: | (1) Medical Research Service, Veterans Administration Medical Center and Department of Medicine, University of Miami School of Medicine, 33125 Miami, Florida, USA;(2) College of Pharmacy, Florida A & M University Clinical Research Unit, P.O. Box 421091, 33142 Miami, Florida, USA;(3) College of Pharmacy, Florida A & M University, 32307 Tallahassee, Florida, USA |
| Abstract: | Summary In the presence of ethanol, corticosterone and dexamethasone inhibit choline acetyltransferase and acetylcholinesterase activities in cultured fetal brain cells of the rat. These results suggest that corticosteroids may have an important influence on the activity of cholinergic enzymes in the fetal brain and may antagonize the effects of ethanol in this setting. |
| Keywords: | Fetal brain cells ethanol corticosterone dexamethasone choline acetyltransferase acetylcholinesterase |
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