Mouse ooplasm confers context-specific reprogramming capacity |
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| Authors: | Michelle M Chan Zachary D Smith Dieter Egli Aviv Regev Alexander Meissner |
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| Institution: | 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3]. |
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| Abstract: | Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes. |
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