| α-氨基芳甲基膦酸二酯的制备 |
| |
| 引用本文： | 徐璇. α-氨基芳甲基膦酸二酯的制备[J]. 科学技术与工程, 2011, 18(18) |
| |
| 作者姓名： | 徐璇 |
| |
| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
| |
| 摘 要： | 以苄胺、芳香醛和亚磷酸二乙酯为主要原料，经过类Mannich和催化氢化脱苄两步反应合成了系列的α-氨基芳甲基膦酸二乙酯，总产率可以达到70%～90%；该方法条件温和、简单、易于操作、适宜于规模化生产，为α-氨基芳甲基膦酸二酯的放大量生产奠定了基础。
|
| 关 键 词： | α-氨基芳甲基膦酸二酯；苄胺；亚磷酸二乙酯 |
| 收稿时间： | 2011-03-24 |
| 修稿时间： | 2011-03-31 |
Preparation of Primary Dialkyl 1-Aminoarylmethylphosphonate |
| |
| xuxuan. Preparation of Primary Dialkyl 1-Aminoarylmethylphosphonate[J]. Science Technology and Engineering, 2011, 18(18) |
| |
| Authors: | xuxuan |
| |
| Affiliation: | XU Xuan,YANG Ri-fang,LIU Ying,YUN Liu-hong,LI Jin(Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,P.R.China) |
| |
| Abstract: | An efficient method was reported for the synthesis of primary 1-Amino- arylmethylphosphonate via two-step reaction of Mannich-type reaction of aromatic aldehyde, benzylamine and diethyl phosphite, and subs -equently catalytic hydro genizing debenzylation. By this method, a series of primary diethyl 1-aminoaryl methy -lphosphonates were prepared in good to excellent yields. This method is facile, easy to handle and suitable for large-scale production of primary dialkyl 1-amino- arylmethylphosphonate. |
| |
| Keywords: | primary dialkyl 1-aminoarylmethylphosphonates benzylamine diethyl phosphite |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《科学技术与工程》浏览原始摘要信息 |
|
点击此处可从《科学技术与工程》下载全文 |
|
