Endothelial cell apoptosis in angiogenesis and vessel regression |
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Authors: | Emma C Watson Leigh Coultas |
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Institution: | 1.Development and Cancer Division,The Walter and Eliza Hall Institute of Medical Research,Parkville,Australia;2.Department of Medical Biology,University of Melbourne,Parkville,Australia;3.Department of Tissue Morphogenesis,Max Planck Institute for Molecular Biomedicine,Münster,Germany;4.Faculty of Medicine,University of Münster,Münster,Germany |
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Abstract: | Blood vessel regression is an essential process for ensuring blood vessel networks function at optimal efficiency and for matching blood supply to the metabolic needs of tissues as they change over time. Angiogenesis is the major mechanism by which new blood vessels are produced, but the vessel growth associated with angiogenesis must be complemented by remodeling and maturation events including the removal of redundant vessel segments and cells to fashion the newly forming vasculature into an efficient, hierarchical network. This review will summarize recent findings on the role that endothelial cell apoptosis plays in vascular remodeling during angiogenesis and in vessel regression more generally. |
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