Role of the microenvironment in myeloid malignancies |
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| Authors: | Marie Goulard Christine Dosquet Dominique Bonnet |
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| Institution: | 1.INSERM, UMRS1131-Paris Diderot University, Saint Louis Hospital,Paris,France;2.Cell Biology Department,APHP, Saint Louis Hospital,Paris,France;3.Haematopoietic Stem Cell Laboratory,The Francis Crick Institute,London,UK |
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| Abstract: | The bone marrow microenvironment (BMM) regulates the fate of hematopoietic stem cells (HSCs) in homeostatic and pathologic conditions. In myeloid malignancies, new insights into the role of the BMM and its cellular and molecular actors in the progression of the diseases have started to emerge. In this review, we will focus on describing the major players of the HSC niche and the role of the altered niche function in myeloid malignancies, more specifically focusing on the mesenchymal stroma cell compartment. |
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