Functional Imaging of Breast Tissue and Clinical Application

0Introduction Near infrared(NIR)techniquesarebasedonsensitive,quantitativemeasurementsoffunctionalcontrastbe tweenhealthyanddiseasedtissue.Recently,researchersshowgreatinterestinmeasuringfunctionalpropertiesofbreasttis suesuchashemoglobinconcentrationoroxygensaturationbyNIRspectroscopyandNIRimaging1,2].NIRlightcanpene trateseveralcentimetersintotissuebeforeitisattenuatedbe lowdetection.ThemainintrinsicmechanismsofNIRlightat tenuationintissuearethescatteringduetoindexofrefractionvariatio…

Functional imaging of breast tissue and clinical application

A novel approach to image hemoglobin concentration(ΔD _hb) and oxygen saturation (ΔD _oxy) of breast tissue is presented. The scenograph of dual-wavelength (760 and 850 nm) near infrared lights through breast tissue is acquired by high sensitive charge coupled device (CCD) camera. The evaluation criterion of the difference of ΔD _hb and ΔD _oxy between detected and referenced breast tissue can be obtained by a calculation formula without complicate caculation. This approach is applied to clinic detection in breast tissue. The ongoing clinical experiments indicate that malignant tumor usually exhibits characterize of “higher ΔD _hb and lower ΔD _oxy”, while benign lesion often shows “lower ΔD _hb and higher ΔD _oxy” or other characters. So it is useful to assist the diagnosis of breast disease. Foundation item: Supported by the Enterprise Innovation Foundation of Wuhan (2-2-0, 2004) Biography: LI Kaiyang(1963-), male, Associate professor, research direction, biomedical physics and biomedical engineering.