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| 头孢菌素C发酵液表观黏度及其对发酵的影响 | |
| 引用本文： | 鲍红霞,王孟强,任璐,贾士儒.头孢菌素C发酵液表观黏度及其对发酵的影响[J].天津科技大学学报,2006,21(4):55-58. |
| 作者姓名： | 鲍红霞 王孟强 任璐 贾士儒 |
| 作者单位： | 1. 天津科技大学生物工程学院,天津市工业微生物重点实验室,天津,300457;河北中润制药有限公司,石家庄,050041 2. 河北中润制药有限公司,石家庄,050041 3. 天津科技大学生物工程学院,天津市工业微生物重点实验室,天津,300457 |
| 摘 要： | 对实际工业化生产发酵过程中头孢菌素C发酵液的表观黏度进行了测定，并且与细胞生长曲线进行了比较。结果表明，头孢菌素C发酵液表观黏度与细胞生长有相关性，随着细胞生长，发酵液的表观黏度呈上升趋势，达到稳定期时，表观黏度趋于稳定。头孢茼素C发酵液表观黏度对发酵效价有明显影响，其机制可能是通过影响溶氧水平、传氧以影响头孢菌素C的生物合成。 |
| 关 键 词： | 头孢菌素C 发酵 表观黏度 细胞生长 分化 |
| 文章编号： | 1672-6510(2006)04-0055-04 |
| 修稿时间： | 2006年3月31日 |
Apparent Viscosity of Cephalosparin C Broth and Its Effect on Fermentation |
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| BAO Hong-xia,WANG Meng-qiang,REN Lu,JIA Shi-ru.Apparent Viscosity of Cephalosparin C Broth and Its Effect on Fermentation[J].Journal of Tianjin University of Science & Technology,2006,21(4):55-58. | |
| Authors: | BAO Hong-xia WANG Meng-qiang REN Lu JIA Shi-ru |
| Abstract: | The apparent viscosity of the cephalosparin C broth in the fermentation process was studied and compared with the cell growth.Results show that there are correlations between the apparent viscosity of the cephalosparin C broth and cell growth.With the growth of cell,the apparent viscosity of broth become ascend tendency.But the apparent viscosity appears steady stage when cell growth is to be steady.The effect on fermentation titer of the cephalosparin C broth apparent viscosity is obvious.The mechanism maybe have something to do with the biosynthesis of CPC though influence DO level and oxygen transmission. |
| Keywords: | cephalosparin C fermentation apparent viscosity cell growth differentiation |
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