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The effect of physostigmine on (Na+ + K+)-ATPase activity in different rat brain regions |
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| Authors: | T Stojanovi? B M Djurici? B B Mrsulja |
| Abstract: | The activity of (Na+ + K+)-ATPase and acetylcholine esterase were followed in rat brain cerebral cortex, caudate, thalamus, hippocampus and medulla after i.v. administration of physostigmine. Both enzymes were found to be inhibited in a dose-dependent manner. The most pronounced inhibition of (Na+ + K+)-ATPase was found in caudate, where the highest activity of acetylcholine esterase is found. |
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