Sensing life: regulation of sensory neuron survival by neurotrophins |
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Authors: | Kirstein M Fariñas I |
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Institution: | (1) Departamento de Biología Celular, Universidad de Valencia, Doctor Moliner 50, 46100 Burjassot (Spain), Fax +34 96 3864372, e-mail: isabel.farinas@uv.es, ES |
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Abstract: | Neurotrophins are a family of structurally and functionally related neurotrophic factors which, in mammals, include: nerve
growth factor, brain-derived neurotrophic factor, neurotrophin-3 (NT-3), and NT-4/5. In addition to their canonical role in
promoting neuronal survival, these molecules appear to regulate multiple aspects of the development of the nervous system
in vertebrates, including neuronal differentiation, axon elongation and target innervation, among others. Actions of neurotrophins
and of their receptors in vivo are being analyzed by loss-of-function or gain-of-function experiments in mice. Here, we review
the phenotypes of the primary sensory system in these mutant mouse strains and the different strategies specifically involved
in the regulation of neuronal survival by neurotrophins in this portion of the nervous system.
Received 10 December 2001; received after revision 11 May 2002; accepted 13 May 2002
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ID="*"Corresponding author. |
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Keywords: | , Neuronal survival, dorsal root ganglia, cranial ganglia, knockout, transgenic mice, |
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