| 抗癌药物长春新碱的微核效应 |
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| 引用本文： | 叶亚新.抗癌药物长春新碱的微核效应[J].苏州科技学院学报(自然科学版),2001,18(1):53-55. |
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| 作者姓名： | 叶亚新 |
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| 作者单位： | 苏州铁道师范学院生物系,苏州,215009 |
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| 基金项目： | 铁道部青年科研基金项目. |
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| 摘 要： | 测定了长春新碱对蚕豆根尖细胞微核千分率的影响,结果在25～50μg/ml浓度下未见增加,但在100～200μg/ml下微核千分率明显增加到14.4～16.4μg/ml(p＜0.05～0.01),这提示长春新碱对细胞有一定的诱变作用,有必要对其遗传毒性进行多角度的研究.
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| 关 键 词： | 长春新碱 微核率 蚕豆根尖 诱变活性 |
| 文章编号： | 1004-5201(2001)01-0053-03 |
| 修稿时间： | 2000年3月27日 |
Study on Micronucleus Effect Caused by Anticancer Drug Vincristinine |
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| YE Ya-xin.Study on Micronucleus Effect Caused by Anticancer Drug Vincristinine[J].Journal of University of Science and Technology of Suzhou,2001,18(1):53-55. |
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| Authors: | YE Ya-xin |
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| Abstract: | Micronucleus effects of Anticancer Drug Vincristinine was detected using the micronucleus test with root tip of Vicia faba. The results showed that the frequency of micronucleus of two vincristinine groups were higher than that of control group. To a certain degree, the frequency of micronucleus showed significant dose dependent relationship . The results indicated that vincristinine has probably mutagenic activity. |
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| Keywords: | Vincristinine micronucleus frequency Vicia faba mutagenic activity |
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