宫颈HPV感染与宫颈瘤样病变的相关性

为了研究湘西地区妇女宫颈人乳头瘤病毒（HPV）感染与宫颈瘤样病变的相关性，为宫颈癌的早期预防提供科学参考，选取692例湘西籍患者为研究对象，所有患者均行宫颈HPV检测，以其中HPV检查结果阳性的234例患者作为观察组，阴性的234例患者作为对照组，均在阴道镜监视下进行宫颈多点活检及宫颈管搔刮病理学检查，病理检测结果分为癌前病变（CINⅠ，Ⅱ，Ⅲ）、宫颈癌、慢性宫颈炎.结果显示：湘西地区女性中HPV感染以HPV16（25.64%）类型最多，其余依次为HPV52，HPV51，HPV58，HPV18，HPV53为常见；CIN的加重程度随HPV感染率升高，CINⅠ，Ⅱ，Ⅲ两两比较差异具有统计意义;HPV阳性率为33.81%，HR-HPV（+）31.74%，其中单一感染HR-HPV（+）21.97%，双重或多重感染11.99%，LR-HPV（+）感染1.88%.说明在宫颈癌的筛查中高危HPV检查具有临床价值，多途径切断高危HPV感染对本地区妇女宫颈癌的一级预防具有重要意义.

Correlation Between Cervical Cancer HPV Infection and Cervical Intraepithelial

To study the correlation between cervical HPV infection and cervical intraepithelial and provide scientific reference basis for prevention, 692 patients in Xiangxi Autonomous Prefecture were randomly selected and received HPV-DNA test. 234 patients with positive result formed the observation group，and 234 patients with negative result formed the control group. Two groups of patients both got a cervical curettage by using colposcope. According to pathology, we divided all results into three parts: precancerosis (CINⅠ, CINⅡ, CINⅢ), cervical cancer and chronic cervicitis. The correlation between cervical HPV infection and cervical intraepithelia was analyzed by statistical software. Results showed that the major type of HPV infection in women of Xiangxi is HPV16 (26.54%), followed by HPV52, HPV51, HPV58, HPV18, HPV53.The increasing degree of CIN increased with HPV infection rate. Among CINⅠ, CINⅡ, CINⅢ, pairwise comparison was statistically significant. The HPV infection rate is 33.81%, and HR-HPV(+) infection rate was 31.74%; 21.97%, 11.99%, 1.88% were single, dual and multiple, and LR-HPV infection respectively. It is concluded that in screening for cervical cancer, clinical value of HR-HPV test should be highly regarded, and it is important to cut off HR-HPV infection in primary prevention of local women cervical cancer.