Development of a new tachykinin antagonist |
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| Authors: | R Mathison P Stofer F Barja H Immer |
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| Institution: | (1) Department of Animal Biology, University of Geneva, 22 Bd. des Philosophes, CH-1205 Geneva, (Switzerland);(2) Bachem Feinchemikalien AG, CH-4416 Bubendorf, (Switzerland) |
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| Abstract: | Summary The mouse urinary bladder possesses a tachykinin receptor which responds to kassinin and eledoisin, but not to some other tachykinins. The action of kassinin, but not that of eledoisin, was blocked in a surmountable manner by a new tachykinin antagonist, D-Pro4, Val8, D-Trp7,9,10 (SP)4–11.Acknowledgments. We thank Mrs Danielle Solomos for technical help. This study was financed by a grant from the Swiss National Science Foundation (3.800-80.2). |
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