基于振动微量下料技术的药物粉末流动性检测方法

传统的药物粉末流动性检测方法对物性接近的粉末流动性差异区分度不高，造成部分受粉末流动性影响较大的工艺缺少对材料进行准确物性评价。针对这一问题，以8种乳糖为药物模型，研究基于振动微量下料技术的药物粉末流动性检测方法。根据粉末流动的质量流量、连续与间断下料的流速变化等情况，由粉体流动方程推导得到下料流速与过程参数间的关系式，给出了表征流动性的特征常数。结果表明，基于振动微量下料技术的药物粉末流动性检测方法适用于中值粒径为20～135 μm的药物粉末，对在这个粒径范围内物性相近的乳糖的流动性有明显的区分度，并具有在其他更多的药物粉末流动性检测中推广的潜力及良好的工业应用价值。

Detection method of drug powder flowability based on vibratory micro-feeding technology

The traditional detection methods of drug powder flowability can not distinguish the difference in the flowability of drug powders with similar physical properties. As a result, for the process, which is greatly affected by the powder flowability, the accurate methods for evaluting the properties of the materials are scarcel. To solve this problem, eight kinds of lactose were used as drug models to study the detection method of drug powder flowability based on vibratory micro-feeding technology. According to the mass flow rate of powder, velocity changes for continuous and intermittent discharge, etc. the relationship between the discharge velocity and process parameters was derived from the powder flow equation. The characteristic constant featuring flowability was given. The results show that this detection method of drug powder flowability based on vibratory micro-feeding technology is suitable for measuring and evaluating the powders with a median particle size of 20～135 μm. A clear distinction between the flowability of lactoses with similar physical properties within this particle size range can be achieved. This method has potential application in other more drug powders and is promising for industrial application.