| 组蛋白甲基化的阅读器识别机制研究进展 |
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| 引用本文： | 赵帅,苏晓楠,李元元,李海涛.组蛋白甲基化的阅读器识别机制研究进展[J].科技导报(北京),2015,33(8):94-100. |
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| 作者姓名： | 赵帅 苏晓楠 李元元 李海涛 |
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| 作者单位： | 清华大学医学院基础医学系, 北京100084 |
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| 基金项目： | 国家自然科学基金面上项目(31270763);教育部新世纪优秀人才支持计划项目 |
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| 摘 要： | 组蛋白甲基化修饰对遗传信息解读有着重要影响,是表观遗传调控的主要机制之一。组蛋白甲基化可以被一类称作"阅读器"的结构域所特异识别并介导下游生物学事件。本文综述了目前已知的组蛋白甲基化阅读器(包括"皇室家族"成员、PHD锌指及BAH 等结构域)的结构特征及其对于甲基化修饰位点和程度特异性识别的分子基础。另外,探讨了表观遗传修饰调控中的组合识别、修饰对话等概念与机制。
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| 关 键 词： | 组蛋白阅读器 组蛋白甲基化 表观遗传调控 组合识别 修饰对话 晶体结构 |
| 收稿时间： | 2014-11-21 |
Research advances in the mechanism of histone methylation recognition by reader modules |
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| ZHAO Shuai,SU Xiaonan,LI Yuanyuan,LI Haitao.Research advances in the mechanism of histone methylation recognition by reader modules[J].Science & Technology Review,2015,33(8):94-100. |
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| Authors: | ZHAO Shuai SU Xiaonan LI Yuanyuan LI Haitao |
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| Institution: | Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China |
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| Abstract: | As a major mechanism for the epigenetic regulation, the histone methylation has a crucial impact on the decoding of the genetic information. The histone methylation can be recognized by a class of so-called "reader" modules to mediate the downstream functional outcomes. In this paper, we review the structural aspects of the reported histone methylation readers (e.g. "royal family" members, PHD finger, BAH), and illustrate the molecular basis underlying the site- and state- specific readouts of the histone methylation. This review also covers the concepts of the combinatorial readout and the modification crosstalk in the epigenetic regulation. |
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| Keywords: | histone reader histone methylation epigenetic regulation combinatorial readout modification crosstalk crystal structure |
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