可溶粒子形貌对磷酸钙骨水泥支架结构和性能的影响

采用可溶粒子造孔法，结合冷等静压成型技术，分别用立方体的氯化钠晶体和短棒状的谷氨酸钠晶体两种不同形貌的造孔粒子制备出具有较高孔隙率和良好抗压强度的磷酸钙骨水泥组织工程支架材料，研究了颗粒形貌对支架材料的显微结构和力学性能的影响。结果表明，造孔粒子形貌决定了制备的磷酸钙骨水泥组织工程支架的孔隙形貌，并影响支架的孔隙率和力学性能。对于相同的加入量，谷氨酸钠晶体作为造孔粒子制备的支架的孔隙率高于氯化钠晶体制备的支架，而用氯化钠造孔粒子制备的支架的强度高于用谷氨酸钠造孔粒子制备的支架。由于在制备过程中引入了等静压处理，支架材料具有良好的强度。

Effect of the Shape of Porogens on the Microstructure and Mechanical Property of the Calcium Phosphate Cement Scaffold

Macroporous calcium phosphate cement (CPC) scaffold for tissue engineering was prepared by a salt-leaching method, using water-dissoluble cubic sodium chloride and rod-like monosodium glutamate crystals as porogens, and cold isostatic pressing treatment in this work. The effect of the shape of porogens on the microstructure and mechanical property of the scaffolds were investigated. The results indicate that the shape of the macropores in the scaffolds depended on the shape of porogens and the shape of the macropores affected the mechanical property of the scaffolds. For the same mass fraction of porogen, the porosity of the scaffold prepared with monosodium glutamate crystals is higher than that of the scaffold prepared with sodium chloride crystals and the compressive strength of the scaffold prepared with sodium chloride crystals is higher than that of the scaffold prepared with monosodium glutamate crystals. The compressive strength of the scaffolds is reasonable good by using cold isostatic pressing technology.