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Common sequence variants on 20q11.22 confer melanoma susceptibility |
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| Authors: | Brown Kevin M Macgregor Stuart Montgomery Grant W Craig David W Zhao Zhen Zhen Iyadurai Kelly Henders Anjali K Homer Nils Campbell Megan J Stark Mitchell Thomas Shane Schmid Helen Holland Elizabeth A Gillanders Elizabeth M Duffy David L Maskiell Judith A Jetann Jodie Ferguson Megan Stephan Dietrich A Cust Anne E Whiteman David Green Adele Olsson Håkan Puig Susana Ghiorzo Paola Hansson Johan Demenais Florence Goldstein Alisa M Gruis Nelleke A Elder David E Bishop Julia Newton Kefford Richard F Giles Graham G Armstrong Bruce K Aitken Joanne F Hopper John L Martin Nicholas G Trent Jeffrey M |
| Institution: | Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85028, USA. |
| Abstract: | We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases. |
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