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Cardiovascular development: towards biomedical applicability
Authors:M Campione  A F Moorman  R G Kelly
Institution:(1) Institute of Neurosciences, University of Padua, Padua, Italy;(2) Department of Anatomy and Embryology, Academic Medical Centre, Amsterdam, The Netherlands;(3) Developmental Biology Institute of Marseilles, CNRS UMR 6216, Campus de Luminy, Case 907, 13288 Marseille, Cedex 9, France
Abstract:Advances in our understanding of cardiac development have fuelled research into cellular approaches to myocardial repair of the damaged heart. In this collection of reviews we present recent advances into the basic mechanisms of heart development and the resident and non-resident progenitor cell populations that are currently being investigated as potential mediators of cardiac repair. Together these reviews illustrate that despite our current knowledge about how the heart is constructed, caution and much more research in this exciting field is essential. The current momentum to evaluate the potential for cardiac repair will in turn accelerate research into fundamental aspects of myocardial biology.
Keywords:Heart development  cardiac repair  stem cells  T-box genes  animal models
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