生物医学研究与科学假说

医学经历了漫长的经验医学和观察医学阶段,由以科学假说为发展形式的基础医学的发展,发展到现代的实验医学阶段。以假定性、科学性和可验证性为特征的科学假说,通常主要以前设的工作假说的形式导引和推动基础医学、实验医学研究。随着高通量、高灵敏度、高专一性诸多高新技术的问世,科学假说将主要以后立的形式总结、导引和推动后基因组时代基础医学、实验医学的发展。在大科学、大发现的发现科学时代,人们在科研基金和论文评审中,将面临如何应对没有明确工作假说但却非常富于创新和高度风险的标书和论文的新情况。

Biomedical Research and Scientific Hypothesis

Medicine has a long history in terms of stage of experience and observational medicine. The stage of modern experimental medicine has been developed based on the development of basic medicine developed mainly in form of scientific hypothesis. Scientific hypothesis is characterized by its supposition, science background and testability. Basic medicine and thus experimental medicine have been guided and pushed forward preliminarily by prior-setup of hypothesis or working hypothesis. Modern experimental medicine would now be summarized, guided and promoted by post-setup hypothesis as high and new techniques with high throughput, high sensitivity and high specificity come out in the era of post-genome. People would be facing a novel situation of how to evaluate the quality of scientific grant and article when they are written without clear hypothesis but rich in creativity and risk in the epoch of discovery science characterized by great science and great discovery.