原位和子宫腺肌病异位内膜Bcl-2的表达

目的：研究原位子宫内膜和子宫腺肌病异位内膜Ｂｃｌ－２在月经周期中的表达情况，并探讨子宫腺肌病和子宫内膜异位症Ｂｃｌ－２不同表达的原因。方法：应用免疫组织化学ＬＳＡＢ方法研究２０例原位子宫内膜和子宫腺肌病异位内膜的Ｂｃ１－２表达。结果：原位子宫内膜腺体的Ｂｃｌ－２表达在月经周期中存在周期性变化：从增生早期至分泌早期，腺上皮细胞均呈Ｂｃｌ－２阳性反应，增生中晚期Ｂｃｌ－２表达最强，至分泌中晚期则表达基

Bcl-2 expression in eutopic endometrimn and uterine adenomyotic tissue

Aim: To investigate Bcl-2 expression in human eutopic endometrium and adenomyotic tissues during the menstrual cycle and discuss the cause of different Bcl-2 expression between uterine adenomyosis and endometriosis. Methods: Bcl-2 expression was studied by an immunohistochemical LSAB method in 20 samples of eutopic and ectopic endometrium in adenomyosis. Results: The expression of Bcl-2 in eutopic endometrial glandular cells was observed at prolifertive through early secretory phases and peaked at the end of proliferative phase, but not at mid and late secretory phases. The expression of Bcl-2 in ectopic glandular cells of adenomyosis showed apparent cyclic changes during the menstrual cycle. Bcl-2 was strongly expressed during the proliferative phase, but weakly expressed during the secretory phase. Conclusion: The cyclic changes of Bcl-2 expression in adenomyotic tissues implied a difference in the pathogenesis or condition of the cells between adenomyosis and endometriosis.