The effect of oxine-5-sulphonic acid on the hepatic drug metabolism in the rat |
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| Authors: | L. Manzo R. Passoni A. D. Segre F. Bertè A. Crema |
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| Affiliation: | (1) Istituto di Farmacologia Medica, Università di Pavia, Piazza Botta 10, I-27100 Pavia, (Italy);(2) Present address: Laboratori Causyth, Via Serio 6, I-20139 Milano, Italy |
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| Abstract: | ![]()
Summary Oxine-5-sulphonic acid inhibits the metabolism of aminopyrine in the rat liver in vitro. The characteristics of this inhibition vary according to whether the oxidativeN-demethylation of the substrate is determined by the formation of the metabolite 4-aminoantipyrine or by the production of formaldehyde. |
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