| 介质研磨法制备阿奇霉素纳米晶 |
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| 引用本文： | 戎欣玉,陈涛,郝小妹,王颖明,王廉卿.介质研磨法制备阿奇霉素纳米晶[J].河北师范大学学报(自然科学版),2012,36(5):502-508. |
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| 作者姓名： | 戎欣玉 陈涛 郝小妹 王颖明 王廉卿 |
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| 作者单位： | 1. 河北科技大学化学与制药工程学院,河北石家庄050018;河北省药物化工工程技术研究中心,河北石家庄050018
2. 河北科技大学化学与制药工程学院,河北石家庄,050018 |
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| 基金项目： | 河北省人力资源和社会保障厅留学人员科技活动择优项目 |
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| 摘 要： | 采用介质研磨法制备了阿奇霉素纳米晶,考察了机器转速、研磨时间、研磨珠的大小及用量、表面活性剂的种类及浓度、阿奇霉素的浓度等因素对产品粒径及多分散指数的影响.分别采用扫描电镜(SEM)、粒度测定仪、X射线粉末衍射(XRPD)、红外光谱仪(FT-IR)对纳米晶进行了分析和表征,同时对纳米晶和原料药进行了溶出性能研究.实验结果表明,在优化的条件下,可制备平均粒径为165nm的阿奇霉素纳米粒子,研磨前后药物的晶态没有明显改变;与原料药相比,纳米晶的溶出度有了显著提高.
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| 关 键 词： | 介质研磨 阿奇霉素 纳米晶 溶出度 |
Preparation of Azithromycin Nanocrystals by Wet Media Milling Technology |
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| RONG Xinyu
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CHEN Tao
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HAO Xiaomei
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WANG Yingming
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WANG Lianqing.Preparation of Azithromycin Nanocrystals by Wet Media Milling Technology[J].Journal of Hebei Normal University,2012,36(5):502-508. |
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| Authors: | RONG Xinyu CHEN Tao HAO Xiaomei WANG Yingming WANG Lianqing |
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| Institution: | 1(1.College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Hebei Shijiazhuang 050018,China; 2.Hebei Research Center of Pharmaceutical and Chemical Engineering,Hebei Shijiazhuang 050018,China) |
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| Abstract: | A wet media milling method was employed to prepare azithromycin(AZM)nanocrystals.The influences on the size and polydispersity index at different rotational speed of the machine,the milling time,different size and weight of grinding beads,different types and concentrations of surfactants and the concentration of AZM were studied.The nanocrystals were characterized by SEM,XRPD and FT-IR,etc.The dissolution rates of the drug nanocrystals and bulk drug were also compared.The results indicated that AZM nanocrystals with an average size of 165 nm could be obtained in the optimum condition.Furthermore,both drugs before and after milling maintained their crystalline state,compared with AZM bulk,the dissolution rate of nanocrystals showed a significant increase. |
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| Keywords: | media milling azithromycin nanocrystals dissolution rate |
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