The pharmacokinetics of VIP in dog and pig |
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| Authors: | S J Mitchell I M Modlin A A J D'Sa Barros S R Bloom |
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| Institution: | (1) Department of Medicine, Hammersmith Hospital, W12 London, (England);(2) Francis Fraser Labs, Royal Postgraduate, Medical School, Hammersmith Hospital, Du Cane Road, W 12 OHS London |
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| Abstract: | Summary Pure porcine VIP was infused systemically in 4 conscious dogs and systemically and intraportally in 6 anesthetized pigs. At 2.3 pmoles·kg–1·min–1 the MCR was 10.7±1.0 ml·kg–1·min–1 in dog and 7.6±1.5 (systemic) and 16.5±2.0 (portal) in pig. The t 1/2's were 1.0±0.12 and 1.0±0.05 respectively. These values agree with those observed in man. This very high single pass tissue clearance does not suggest a hormonal role for VIP. |
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