| K6H2［CoW11TiO40］纳米脂质体复合物的制备及性质研究 |
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| 引用本文： | 杨勇.K6H2［CoW11TiO40］纳米脂质体复合物的制备及性质研究[J].重庆师范大学学报(自然科学版),2005,22(3):94-97. |
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| 作者姓名： | 杨勇 |
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| 作者单位： | 重庆师范大学,化学学院,重庆,400047 |
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| 摘 要： | 制备了包封多酸化合物K6H2CoW11TiO40] (缩写为CoW11Ti)的纳米脂质体复合物,对其物理化学性质、包封率和含药量、粒度粒径、体外释药量及其体外抗肿瘤活性进行了研究.实验表明,多酸纳米脂质体复合物包封率为45%,含药量为23%,粒径分布在62.2～76.7nm范围内,平均粒径为69.4nm.在4℃可以稳定存在3个月.多酸化合物被包封于纳米脂质体后,活性明显高于原多酸化合物.
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| 关 键 词： | 多酸化合物 纳米脂质体 生物活性 |
| 文章编号： | 1672-6693(2005)03-0094-04 |
| 修稿时间： | 2004年11月22 |
Characterization and Diological Activity of the Polyoxometalate K6H2[CoW11TiO40] Incorporated Nanosized-liposome |
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| YANG Yong.Characterization and Diological Activity of the Polyoxometalate K6H2[CoW11TiO40] Incorporated Nanosized-liposome[J].Journal of Chongqing Normal University:Natural Science Edition,2005,22(3):94-97. |
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| Authors: | YANG Yong |
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| Abstract: | The polyoxometalate K_6H_2CoW_(11)TiO_(40)] ( abbreviated as CoW_(11)Ti ) incorporated nanosized-liposome has been prepared and the shape, size-distribution, encapsulate ratio of the liposome and the content of the drug in the complex have been investigated. The experimental results show that the antitumoral activity of CoW_(11)Ti incorporated nanosized-liposome is higher than that of CoW_(11)Ti. |
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| Keywords: | polyoxometalates nanosized-liposome biological activity |
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