| 南宁地区肝细胞性肝癌中突变型p53蛋白表达 |
| |
| 引用本文： | 邓卓霖,马韵,罗虹.南宁地区肝细胞性肝癌中突变型p53蛋白表达[J].广西科学,1995,2(1):55-57. |
| |
| 作者姓名： | 邓卓霖 马韵 罗虹 |
| |
| 作者单位： | 广西医科大学 |
| |
| 摘 要： | 用ＡＢＣ免疫组织化学方法，对南宁地区居民中１３例肝细胞性肝癌（ＨＣＣ）的活检组织进行研究。发现其中８例有突变型ｐ＾５３蛋白呈强阳性表达，占ＨＣＣ病例数６４．３％。南宁地区某些县，如扶绥县是我国著名的ＨＣＣ高发区，不但ＨＢＶ感染率高，而且是全国少有的ＡＦＢ１高污染区，后者的作用不能忽视。与江苏启东和南部非洲ＨＣＣ高发区一样，估计也会出现ｐ＾５３基因突变热点。
|
| 关 键 词： | p^53蛋白 肝细胞性肝癌 黄曲霉毒素B1 肝癌 |
| 收稿时间： | 1994/12/8 0:00:00 |
p53 Mutation Protein ExPrssion in Hepatocellular Carcinoma in Nanning District |
| |
| Deng Zhuolin,Ma Yun and Luo Hong.p53 Mutation Protein ExPrssion in Hepatocellular Carcinoma in Nanning District[J].Guangxi Sciences,1995,2(1):55-57. |
| |
| Authors: | Deng Zhuolin Ma Yun and Luo Hong |
| |
| Institution: | Guangxi Medical University, 6 Binhu Road, Nanning, Guangxi, 530021,Guangxi Medical University, 6 Binhu Road, Nanning, Guangxi, 530021 and Guangxi Medical University, 6 Binhu Road, Nanning, Guangxi, 530021 |
| |
| Abstract: | Immunohistochemistry ABC method was used to study 13 biopsy casses of hepatocellular carcinoma (HCC) in Nanning prefectural district. Eight cases (64. 3%) were found to have positive expression of p53 mutation protein. Fu-Sui and its surrounding counties in the district are notorious for their high HCC incidence in China, not only high in infection of hepatitis B Verus (HBV) but also high in contamination of aflatoxin B1 (AFB1 ), and both are putative risk factors of HCC. The AFB1 could injure the DNA and cause a mutational hotspot in the p53gene. Thus its effect should not be neglected. |
| |
| Keywords: | p53 Protein hepatocellular carcinoma aflatoxin |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《广西科学》浏览原始摘要信息 |
| 点击此处可从《广西科学》下载免费的PDF全文 |
|
