Membrane shaping by the Bin/amphiphysin/Rvs (BAR) domain protein superfamily |
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Authors: | Yijian Rao Volker Haucke |
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Institution: | 1.Institute of Chemistry and Biochemistry,Freie Universit?t Berlin,Berlin,Germany;2.NeuroCure Cluster of Excellence,Charité Berlin,Berlin,Germany;3.Leibniz-Institut für Molekulare Pharmakologie (FMP),Berlin,Germany;4.Max Planck Institute for Biochemistry,Martinsried,Germany |
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Abstract: | BAR domain superfamily proteins have emerged as central regulators of dynamic membrane remodeling, thereby playing important
roles in a wide variety of cellular processes, such as organelle biogenesis, cell division, cell migration, secretion, and
endocytosis. Here, we review the mechanistic and structural basis for the membrane curvature-sensing and deforming properties
of BAR domain superfamily proteins. Moreover, we summarize the present state of knowledge with respect to their regulation
by autoinhibitory mechanisms or posttranslational modifications, and their interactions with other proteins, in particular
with GTPases, and with membrane lipids. We postulate that BAR superfamily proteins act as membrane-deforming scaffolds that
spatiotemporally orchestrate membrane remodeling. |
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