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MGB probe assay for rapid detection of mtDNAl1778 mutation in the Chinese LHON patients by real-time PCR |
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| Authors: | Jian-yong WANG, Yang-shun GU, Jing WANG, Yi TONG, Ying WANG, Jun-bing SHAO, Ming QI |
| Affiliation: | [1]Department of Ophthalmology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; [2]Department of Ophthalmology, the First Affiliated Hospital, Fujian Medical University, Fuzhou 325000, China; [3]Department of Ophthalmology, Eye Hospital, Academy of Chinese Medical Science, Beijing 100040, China; [4]Institute of Biotechnology, Shanghai Zhijiang Biotech Incorporation, Shanghai 210038, China; [5]Institute of Genome Sciences, University of Rochester Medical Center, Rochester, NY 14642, USA |
| Abstract: | Leber＇s hereditary optic neuropathy （L HON）, Mitochondrial DNA （mtDNA）, MtDNA 11778 mutation, Minor groove binder （MGB） orobe. Real-time oolvmerase chain reaction （PCR） |
| Keywords: | Leber＇s hereditary optic neuropathy （L HON） Mitochondrial DNA （mtDNA） MtDNA 11778 mutation Minor groove binder （MGB） orobe. Real-time oolvmerase chain reaction （PCR） |
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