| 新型高效透皮吸收促进剂——月桂氮酮Azone的合成 |
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| 引用本文： | 周瑞仪,陈毅辉,赵海燕,郭奇珍.新型高效透皮吸收促进剂——月桂氮酮Azone的合成[J].厦门大学学报(自然科学版),1988(6). |
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| 作者姓名： | 周瑞仪 陈毅辉 赵海燕 郭奇珍 |
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| 作者单位： | 厦门大学化学系
(周瑞仪，陈毅辉，赵海燕)，厦门大学化学系(郭奇珍) |
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| 摘 要： | 以聚乙二醇(PEG)为相转移催化剂(PTC),在固-液相转移条件下,制得Azone,实验结果表明:PTC以PEG-400为好,当反应温度为100～110℃时,反应时间短(10h),产率较高达71.3～72.8％,操作简便和成本较低等优点。
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| 关 键 词： | 透皮吸收促进剂 祖转移催化剂 聚乙二醇 月?氮?酮 Azone |
Synthesis of Azone-A Novel Ferenationn Erhancer |
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| Zhow Ruiyi Chen Yihui Zhao Haiyan Guo Qizhen.Synthesis of Azone-A Novel Ferenationn Erhancer[J].Journal of Xiamen University(Natural Science),1988(6). |
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| Authors: | Zhow Ruiyi Chen Yihui Zhao Haiyan Guo Qizhen |
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| Institution: | Dept. of Chem. |
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| Abstract: | Azone is a rovel and tortexid pctertial penetration enhance. It was synthesized by means of solid-liquid phase transfer catalysis of polye thylene glycol. The procedure is simple to operate, with short reaction time and with good yield. The experimental results were discussed. |
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| Keywords: | Penetratioa enhancer Phase tranfer catalyst Polyethylene glycol Azone |
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