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A cannabinoid with cardiovascular activity but no overt behavioral effects |
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| Authors: | M. D. Adams J. T. Earnhardt B. R. Martin L. S. Harris W. L. Dewey R. K. Razdan |
| Affiliation: | (1) Department of Pharmacology, Medical College of Virginia, 23298 Richmond, Virginia, USA;(2) Sheehan Institute for Research, Inc., 02138 Cambridge, Massachusetts, USA |
| Abstract: | Summary Abnormal- 8-tetrahydrocannabidiol (ABN-8-THC) failed to elicit central nervous system and cardiovascular effects in laboratory animals. Abnormal-cannabidiol (ABN-CBD) was also devoid of overt behavioral effects but produced marked hypotension with only slight bradycardia in anesthesized dogs.Acknowledgment. This work was supported by NIDA (grant No. DA-00574-01 and DA-00490) and Virginia Heart Society (grant No. RR-05697) |
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