The hypothalamus and the neurobiology of drug seeking |
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Authors: | Email author" target="_blank">Nathan?J?MarchantEmail author E?Zayra?Millan Email author" target="_blank">Gavan?P?McNallyEmail author |
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Institution: | (1) School of Psychology, University of New South Wales, Sydney, NSW, 2052, Australia |
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Abstract: | The hypothalamus is a neural structure critical for expression of motivated behaviours that ensure survival of the individual
and the species. It is a heterogeneous structure, generally recognised to have four distinct regions in the rostrocaudal axis
(preoptic, supraoptic, tuberal and mammillary). The tuberal hypothalamus in particular has been implicated in the neural control
of appetitive motivation, including feeding and drug seeking. Here we review the role of the tuberal hypothalamus in appetitive
motivation. First, we review evidence that different regions of the hypothalamus exert opposing control over feeding. We then
review evidence that a similar bi-directional regulation characterises hypothalamic contributions to drug seeking and reward
seeking. Lateral regions of the dorsal tuberal hypothalamus are important for promoting reinstatement of drug seeking, whereas
medial regions of the dorsal tuberal hypothalamus are important for inhibiting this drug seeking after extinction training.
Finally, we review evidence that these different roles for medial versus lateral dorsal tuberal hypothalamus in promoting
or preventing reinstatement of drug seeking are mediated, at least in part, by different populations of hypothalamic neurons
as well as the neural circuits in which they are located. |
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