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Induction of hemopoietic chimerism in the caprine fetus by intraperitoneal injection of fetal liver cells |
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| Authors: | R. D. Pearce D. Kiehm D. T. Armstrong P. B. Little J. W. Callahan L. R. Klunder J. T. R. Clarke |
| Affiliation: | (1) Department of Pediatrics and University of Toronto, The Hospital for Sick Children, M5G 1X8 Toronto, Ontario, Canada;(2) MRC Group in Reproductive Biology, University Hospital, N6A 5A5 London, Ontario, Canada;(3) Department of Pathology, Ontario Veterinary College, University of Guelph, N1G 2W1 Guelph, Ontario, Canada;(4) Cytogenetics Laboratory, George D. Widener Hospital for Large Animals, New Bolton Center, University of Pennsylvania, 19348 Kennett Square, Pennsylvania, USA |
| Abstract: | Summary Intraperitoneal injection of allogeneic liver cells from 43-day-old male fetuses into normal 60-day female goat fetuses resulted in persistent hemopoietic chimerism in surviving recipients without clinical evidence of graft-versus-host disease. Transplantation of normal fetal liver cells into preimmunocompetent goat fetuses affected with  -D-mannosidosis may provide an alternative strategy for evaluating hemopoietic stem cell transplantation in the treatment of human lysosomal storage diseases. |
| Keywords: | Transplantation goat fetal liver |
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