| 麻风病人血液超氧化物歧化酶和谷胱甘肽过氧化物酶活性测定分析 |
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| 引用本文： | 李孟森,葛琦,周代锋,周玉英,周勇.麻风病人血液超氧化物歧化酶和谷胱甘肽过氧化物酶活性测定分析[J].海南大学学报(自然科学版),1996(1). |
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| 作者姓名： | 李孟森 葛琦 周代锋 周玉英 周勇 |
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| 作者单位： | 海南医学院生物化学教研室，海南省秀英医院 |
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| 摘 要： | 人体内的超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）．是清除和ＯＨ、ＲＯＯＨ等自由基的主要酶．通过测定正常人、麻风病人的血液ＳＯＤ、ＧＳＨ－ＰＸ活性．探讨麻风病人血液ＳＯＤ、ＧＳＨ－ＰＸ变化对自由基清除的影响．结果显示：麻风病人体内的ＳＯＤ和ＧＳＨ－ＰＸ活性显著低于正常人（Ｐ＜０．０１）；而现症和治愈、多菌型和少菌型、活动期和消退期病人之间无显著性差异（Ｐ＞０．０５）．提示ＳＯＤ和ＧＳＨ－ＰＸ活性降低与麻风杆菌感染有关．且感染麻风菌后病人治愈前后血液中的ＳＯＤ和ＧＳＨ－ＰＸ活性没有明显变化．
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| 关 键 词： | 麻风 过氧化物歧化酶 谷胱甘肽过氧化物酶 自由基 |
Analysis of Blood Superoxide Dismutase and Glutathione Perxiodase Activity in Leprosy Patients |
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| Li Mengsen, Ge Qi, Zhou Yuying,et al..Analysis of Blood Superoxide Dismutase and Glutathione Perxiodase Activity in Leprosy Patients[J].Natural Science Journal of Hainan University,1996(1). |
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| Authors: | Li Mengsen Ge Qi Zhou Yuying |
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| Abstract: | Superoxide dismutase (SOD) and glutathione peroxidase (GSH - PX) are importantenzymes decontaminating free radicals (OH, ROOH) in human bodies. Our work shows thatblood SOD and GSH - PX activity in leprosy patients is remarkably lower (P< 0. 01 ) than that innormal humans. However, there is no significant difference between the patients and the curedones, between the multibacillary (MB) and paucibacillary (PB) patients, or between the patientsin actived period and in declined period (P > 0. 05 ). Our investigation suggests that lower bloodSOD and GSH - PX activity in leprosy patients is related to the infection of leprosy bacteria andthere is no change of blood SOD and GSH - PX activity even after being cured. |
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| Keywords: | leprosy superoxide dimsutase glutathione peroxidase free radicals |
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