Differential regulation of collagen types I and III expression in cardiac fibroblasts by AGEs through TRB3/MAPK signaling pathway |
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Authors: | M Tang M Zhong Y Shang H Lin J Deng H Jiang H Lu Y Zhang W Zhang |
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Institution: | (1) Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, P. R. China;(2) Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, P. R. China;(3) Department of Cardiology, Qilu Hospital of Shandong University, Ji’nan City, Shandong Province, Jinan, P. R. China;(4) The Second Affiliated Hospital of Fujian Medical University, Quanzhou, P. R. China;(5) Department of Anatomy, Shandong University, Jinan, P. R. China |
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Abstract: | Advanced glycation end products (AGEs) play an important role in collagen deposition in diabetic cardiomyopathy. TRB3, a mammalian
homolog of Drosophila tribbles, functions to increase glucose intolerance and regulates cell proliferation. We demonstrated
that AGEs induce collagen type I expression but inhibit collagen type III expression, accompanied by increased TRB3 expression.
Furthermore, the collagen type I induced byAGEs was down-regulated after inhibition of ERK and p38-MAPK, the collagen type
III reduced by AGEs was up-regulated after inhibition of ERK. The expression of collagen types I and III regulated by AGEs
through MAPK was partly reversed after treatment with TRB3 siRNA. It suggests that the TRB3/MAPK signaling pathway participates
in the regulation of collagen types I and III by AGEs and may provide new therapeutic strategies for diabetic cardiomyopathy.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
Received 08 May 2008; received after revision 25 June 2008; accepted 22 July 2008
M. Tang, M. Zhong: These two authors contributed equally to this work. |
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Keywords: | " target="_blank"> Advanced glycation end products cardiac fibroblasts collagen tribble 3 mitogen-activated protein kinase |
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