Hedgehog signaling in pancreas development and disease |
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| Authors: | J Lau H Kawahira M Hebrok |
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| Institution: | (1) Diabetes Center and Department of Medicine, University of California, San Francisco, 513 Parnassus Ave., San Francisco, California 94143, USA;(2) Present address: Larry L. Hillblom Islet Research Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, 900A Weyburn Place North, Los Angeles, California 90095-707322, USA |
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| Abstract: | Since its discovery, numerous studies have shown that the Hedgehog (Hh) signaling pathway plays an instrumental role during
diverse processes of cell differentiation and organ development. More recently, it has become evident that Hh signaling is
not restricted to developmental events, but retains some of its activity during adult life. In mature tissues, Hh signaling
has been implicated in the maintenance of stem cell niches in the brain, renewal of the gut epithelium and differentiation
of hematopoietic cells. In addition to the basal function in adult tissue, deregulated signaling has been implicated in a
variety of cancers, including basal cell carcinoma, glioma and small cell lung cancer. Here, we will focus on the role of
Hh signaling in pancreas development and pancreatic diseases, including diabetes mellitus, chronic pancreatitis and pancreatic
cancer.
Received 5 August 2005; received after revision 4 November 2005; accepted 22 November 2005 |
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| Keywords: | Hedgehog Indian Hedgehog Desert Hedgehog pancreas development pancreatic cancer chronic pancreatitis islets of Langerhans |
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