Highly sensitive biosensors based on water-soluble conjugated polymers |
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Authors: | Xu?Hui Wu?Haiping Email author" target="_blank">Fan?ChunhaiEmail author Li?Wenxin Zhang?Zhizhou He?Lin |
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Institution: | (1) Division of Nanobiology and Pharmacology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 201800 Shanghai, China;(2) Graduate School of Chinese Academy of Sciences, 100039 Beijing, China;(3) Bio-x, Shanghai Jiao Tong University, 200030 Shanghai, China |
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Abstract: | Conjugated, conductive polymers are a kind of important organic macromolecules, which has found applications in a variety
of areas. The application of conjugated polymers in developing fluorescent biosensors represents the merge of polymer sciences
and biological sciences. Conjugated polymers are very good light harvesters as well as fluorescent polymers, and they are
also “molecular wires”. Through elaborate designs, these important features, i.e. efficient light harvesting and electron/energy
transfer, can be used as signal amplification in fluorescent biosensors. This might significantly improve the sensitivity
of conjugated polymer-based biosensors. In this article, we reviewed the application of conjugated polymers, via either electron
transfer or energy transfer, to detections of gene targets, antibodies or enzymes. We also reviewed recent efforts in conjugated
polymer-based solid-state sensor designs as well as chip-based multiple target detection. Possible directions in this conjugated
polymer-based biosensor area are also discussed. |
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Keywords: | conjugated polymer biosensor fluorescent detection gene detection solid-state sensors |
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