新型偶氮染料中间体2-氨基-5-氨甲基-1-萘磺酸合成条件的研究

2-氨基 - 5 -氨甲基 - 1-萘磺酸 (氨甲基吐丝酸 )是一种新型活性偶氮染料中间体 ,文献报道大多采用首先把 2 -氨基 - 1-萘磺酸的氨基乙酰化保护 ,然后氨甲基化及水解反应的合成方法 ,其不仅合成步骤长 ,而且需要在高压反应釜中进行。这样的制备条件在实验室操作以及进一步中试及工业化的生产中存在很大局限性。针对这种情况 ,本研究工作对反应条件进行系统的研究后 ,改用直接将 2 -氨基 - 1-萘磺酸氨甲基化合成 2 -氨基 - 5 -氨甲基 - 1-萘磺酸 (氨甲基吐丝酸 )的方法 ,去掉了氨基乙酰化反应 ,使反应步骤简化 ;去掉了高压操作 ,使整个反应过程容易操作。改进的合成方法反应条件温和 ,整体收率稳定 ,维持在 87.2 % ,获得了较好结果。

Study on the Synthesis of 2-Amino-5-aminomethyl-1-naphthalenesulfonic acid

amino 5 aminomethyl 1 naphthalenesulfonic aci d(Amino methyl Tobias)was used as important intermediates in manufacture of re active azo dyes and dyeing auxiliaries.It had been reported that Amino methyl Tobias was prepared by acetylacylation,aminomethylation and hydrolysis of 2 ami no 1 naphthalenesulfonic acid (Tobias acid).The synthetic steps of the referen ce method were very complexity and need operation in high pressure condition,whi ch have many limitations for operation in laboratory and industry production.In comparison with the reference synthetic conditions,2 amino 5 aminomethyl 1 naphthalenesulfonic acid (Amino methyl Tobias) was prepared only by amino meth ylation and hydrdysis of 2 amino 1 naphthalenesulfonic acid(Tobias acid)in ne wly synthetic conditions,which need not react with acetic anhydride for amin o protection.The method can not only simp lify the synthtic steps but also avoid of high pressure operation;the operation is easier and the reactive conditions is moderate.The yield of 2 amino 5 ami nomethyl 1 naphthalenesulfonic acid(Amino methyl Tobias)was 87.2%.