| 胰岛素第二信使研究进展 |
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| 引用本文： | 张永忠,曹雪松.胰岛素第二信使研究进展[J].聊城大学学报(自然科学版),2000(2). |
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| 作者姓名： | 张永忠 曹雪松 |
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| 作者单位： | 聊城师范学院生物系!聊城252059 |
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| 摘 要： | 近来的许多研究表明有两类分子可作为胰岛素信号传递的第二信使而将激素所携带的信号传递进入靶细胞内 .一类是磷酸寡聚糖或肌醇磷酸多糖 ,另一类是二酰基甘油 (dicylglycerol DAG) .胰岛素对代谢的调节作用是通过磷酸寡聚糖控制代谢关键酶的磷酸化状态而实现的 .二酰基甘油可介导胰岛素刺激葡萄糖的跨膜转运过程 .许多证据表明位于细胞穴样内陷在胰岛素信号传递过程中具有聚集信号传递分子的作用 .
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| 关 键 词： | 第二信使 胰岛素 胞膜穴样内陷 受体 |
Progress in the Study of Insulin Second Mesengers |
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| Zhang Yongzhong,Cao Xuesong.Progress in the Study of Insulin Second Mesengers[J].Journal of Liaocheng University:Natural Science Edition,2000(2). |
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| Authors: | Zhang Yongzhong Cao Xuesong |
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| Abstract: | Lately two molecules have been proposed as second messengers transducing the insulin signal into the target cell.One is a phosphooligosaccharide/inositolphosphoglycan and the other is diacylglycerol.The phospho\|oligosaccharide appears to mediate many metabolic effects of insulin through control of the phosphorylation state of Key regulatory metabolic enzymes.Diacylglycerol may mediate insulin's stimulation of glucose transport over the plasma membrane.It has been shown that the caveolae of the plasma membrane has a focal role in insulin signalling. |
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| Keywords: | Second messengers Insulin Caveolae Receptor |
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