Signalling in viral entry |
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Authors: | U F Greber |
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Institution: | (1) University of Zürich, Institute of Zoology, Winterthurerstrasse 190, 8057 Zürich (Switzerland), Fax: +41 1 635 6822, e-mail: ufgreber@zool.unizh.ch , CH |
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Abstract: | Viral infections are serious battles between pathogens and hosts. They can result in cell death, elimination of the virus
or latent infection keeping both cells and pathogens alive. The outcome of an infection is often determined by cell signalling.
Viruses deliver genomes and proteins with signalling potential into target cells and thereby alter the metabolism of the host.
Virus interactions with cell surface receptors can elicit two types of signals, conformational changes of viral particles,
and intracellular signals triggering specific cellular reactions. Responses by cells include stimulation of innate and adaptive
immunity, growth, proliferation, survival and apoptosis. In addition, virus-activated cell signalling boosts viral entry and
gene delivery, as recently shown for adenoviruses and adeno-associated viruses. This review illustrates that multiple activation
of host cells during viral entry profoundly impacts the elaborate relationship between hosts and viral pathogens.
Received 13 September 2001; received after revision 23 October 2001; accepted 16 November 2001 |
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Keywords: | , Entry, receptor, signal transduction, trafficking, virus infection, |
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