Study on mimetic peroxidase and molecular recognition of phenols with inclusion complex of ironporphyrin immobilized by β-CD polymer |
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Authors: | Mao Lu-yuan Yuan Hong Cai Ru-xiu Shen Han-xi Zhu Min Liu Liu-zhan |
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Institution: | (1) College of Chemistry and Environmental Science, Wuhan University, 430072 Wuhan, China;(2) College of Chemistry, Nankai University, 300071 Tianjian, China |
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Abstract: | β-Cyclodextrin (β-CD) and its cross-linked polymer (β-CDP) were known as the mimetic models. Metalloporphyrin had been widely
used in the enzymatic method of analysis and molecular recognition. In present work, it was investigation that supramolecular
recognition for halogenated phenols, three crosols, three nitrophenols and three aminophenols, served respectively as the
substrate of the mimetic receptor, iron-5, 10, 15, 20-tetrakis (sulforphenyl)-21H, 23H-porphine (FeTPPS) or FeTPPS-β-CDP.
Supramolecular complex, FeTPPS-β-CDP with function of mult i-recognition and induced-fit, was a advanced kind of mimetic peroxidase;
Methyl phenol or polyphenol was the substitute of chlorophenic acid, while aminophenols and other phenols were suggested not
to be utilized to enzymatic assay of H2O2. Being a mimetic enzyme mimicking the space structure of overall proteinase, beaimed by immobilized mimetic enzyme with a
large number of β-CD interior cavities, chlorophenol was identified optimal substrate in the system tested.
Foundation item: Supported by the National Natural Science Foundation of China
Biography: MAO Lu-yuan(1959-), male, Associate Professor, Postdoctor. |
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Keywords: | β -CD polymer metalloporphyrin mimetic enzyme molecular recognition CLC number O 567 3 O 477 |
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