The antifertility action ofa-chlorohydrin: Enzyme inhibition bya-chlorohydrin phosphate |
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| Authors: | P M Mashford A R Jones |
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| Institution: | (1) Department of Biochemistry, University of Sydney, 2006 Sydney, NSW, Australia |
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| Abstract: | Summary Preparations of the enzymes glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase are shown to be inhibited bya-chlorohydrin phosphate (II) in a competitive and non-competitive manner, respectively.a-Chlorohydrin (I), glycidol and epi-chlorohydrin have no inhibitory activities suggesting that their antifertility actions are due to their metabolism in vivo toa-chlorohydrin phosphate. |
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