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Antioxidant effects on prostaglandin synthesis in rabbit kidney medulla slices
Authors:T. Fujita  Y. Fujimoto  H. Tanioka
Affiliation:(1) Department of Hygienic Chemistry, Osaka College of Pharmacy, Kawai, 580 Matsubara, Osaka, Japan
Abstract:Summary Sodium diethyldithiocarbamate, 2,6-di-tert-butylphenol and N,Nprime-diphenyl-p-phenylenediamine inhibited the generation of medullary prostaglandin E, but 1,2-dimethoxyethane (OH scavenger) and 2,5-dimethylfuran (1O2 scavenger) stimulated basal prostaglandin E production 1.2–1.3-fold. These results suggest that the balance between formation and removal of cellular lipid peroxides sets a peroxide level that can regulate the rate of prostaglandin formation in cells.
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