| GC-MS法测定银杏内酯B(原料药)中石油醚残留量 |
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| 引用本文： | 束磊,谢慧明.GC-MS法测定银杏内酯B(原料药)中石油醚残留量[J].安徽大学学报(自然科学版),2012(1):104-108. |
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| 作者姓名： | 束磊 谢慧明 |
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| 作者单位： | 合肥师范学院生命科学系;合肥工业大学生物与食品工程学院 |
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| 基金项目： | 国家重大新药创制科技重大专项基金资助项目(2008ZX09101-018) |
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| 摘 要： | 作者建立了检测银杏内酯B(原料药)中石油醚(60～90℃)残留的方法.以甲醇为萃取溶剂,采用超声提取法对样品进行前处理,采用气相色谱-质谱联用法进行检测.结果表明:该法在5 min内能较好地分离石油醚的所有组分,样品的加样回收率(n=6)为98.8%,RSD为2.55%,低检测限为1.61×10-5μg.该法具有灵敏、准确、快速等特点.
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| 关 键 词： | 银杏内酯B 石油醚残留 气相色谱-质谱联用法 |
Determination of petroleum ether residues in ginkgolide B(bulk drug) by GC-MS |
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| SHU Lei,XIE Hui-ming.Determination of petroleum ether residues in ginkgolide B(bulk drug) by GC-MS[J].Journal of Anhui University(Natural Sciences),2012(1):104-108. |
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| Authors: | SHU Lei XIE Hui-ming |
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| Institution: | 1.Department of Life Science,Hefei Normal University,Hefei 230601,China; 2.School of Biotechnology and Food Engineering,Hefei University of Technology,Hefei 230009,China) |
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| Abstract: | A method has been developed for the simultaneous determination of petroleum ether(60-90 ℃)residues(including ethanol and ethyl acetate) in ginkgolide B(bulk drug).The organic residues were extracted from samples by ultrasonic extraction with methanol and analyzed by gas chromatography-mass spectrometry.The results showed that all the components were separated well in 5 min.The recoveries for spiked standards(n= 6) were 98.8%.The relative standard deviations were 2.55%.The detection limit was 1.61×10-5 μg.This method is sensitive,accurate and quick. |
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| Keywords: | ginkgolide B petroleum ether residues gas chromatography-mass spectrometry |
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