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| TFH细胞调控因子研究进展 | |
| 引用本文： | 陈侃,李志刚,潘兰兰,邱梦芸.TFH细胞调控因子研究进展[J].科学通报,2013,58(10):901-906. |
| 作者姓名： | 陈侃 李志刚 潘兰兰 邱梦芸 |
| 作者单位： | 浙江理工大学生命科学学院, 新元医学与生物技术研究所, 杭州 310018; 浙江理工大学机械与自动控制学院, 杭州 310018 |
| 基金项目： | 浙江省科技厅公益性技术应用研究计划(2012C37069);浙江省重中之重学科开放基金(SWYX0812)和浙江理工大学科研启动基金(0916819-Y)资助 |
| 摘 要： | 滤泡辅助性T细胞(T follicular helper cell, TFH)是CD4+ T细胞家族的新成员, TFH细胞不但在辅助生发中心(germinal center, GC)形成和维持的过程中发挥重要作用, 也是辅助GC中B细胞分化为浆细胞的关键因素. 近年来的研究已证实, Bcl-6是调控TFH细胞分化的重要分子, TFH细胞通过分泌细胞因子IL-21而作用于滤泡B细胞, 以促其分化. 本文就调节TFH细胞分化的主要因子及其作用机制作一综述. |
| 关 键 词： | TFH细胞 CD4+ T细胞 调控因子 |
| 收稿时间： | 2011-12-30 |
Introduction to TFH cell regulatory factors |
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| CHEN Kan,LI ZhiGang,PAN LanLan,QIU MengYun.Introduction to TFH cell regulatory factors[J].Chinese Science Bulletin,2013,58(10):901-906. | |
| Authors: | CHEN Kan LI ZhiGang PAN LanLan QIU MengYun |
| Institution: | 1 School of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China; 2 School of Mechanical and Automation, Zhejiang Sci-Tech University, Hangzhou 310018, China |
| Abstract: | Follicular helper T cells (TFH cell) are a new member of the CD4+ T cell family. They are a key factor in the process of germinal center (GC) formation and maintenance, but also have a significant role in supporting GC B cells differentiate into plasma cells. Recent studies have confirmed that Bcl-6 is an important regulatory molecule for TFH cell differentiation, and by secreting cytokines such as IL-21 they can promote the differentiation of follicular B cells. This article will review the regulatory factors and mechanisms involved in the course of TFH cell differentiation. |
| Keywords: | TFH cell CD4+ T cell regulatory factor |
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