A road map for efficient and reliable human genome epidemiology |
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Authors: | Ioannidis John P A Gwinn Marta Little Julian Higgins Julian P T Bernstein Jonine L Boffetta Paolo Bondy Melissa Bray Molly S Brenchley Paul E Buffler Patricia A Casas Juan Pablo Chokkalingam Anand Danesh John Smith George Davey Dolan Siobhan Duncan Ross Gruis Nelleke A Hartge Patricia Hashibe Mia Hunter David J Jarvelin Marjo-Riitta Malmer Beatrice Maraganore Demetrius M Newton-Bishop Julia A O'Brien Thomas R Petersen Gloria Riboli Elio Salanti Georgia Seminara Daniela Smeeth Liam Taioli Emanuela Timpson Nic Uitterlinden Andre G Vineis Paolo Wareham Nick Winn Deborah M Zimmern Ron |
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Affiliation: | Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina 45110, Greece. jioannid@cc.uoi.gr |
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Abstract: | Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases. A Network of Investigator Networks has been set up to drive the process, sponsored by the Human Genome Epidemiology Network. A workshop is planned to develop consensus guidelines for reporting results of genetic association studies. Published literature databases will be integrated, and unpublished data, including 'negative' studies, will be captured by online journals and through investigator networks. Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews. |
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