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A road map for efficient and reliable human genome epidemiology
Authors:Ioannidis John P A  Gwinn Marta  Little Julian  Higgins Julian P T  Bernstein Jonine L  Boffetta Paolo  Bondy Melissa  Bray Molly S  Brenchley Paul E  Buffler Patricia A  Casas Juan Pablo  Chokkalingam Anand  Danesh John  Smith George Davey  Dolan Siobhan  Duncan Ross  Gruis Nelleke A  Hartge Patricia  Hashibe Mia  Hunter David J  Jarvelin Marjo-Riitta  Malmer Beatrice  Maraganore Demetrius M  Newton-Bishop Julia A  O'Brien Thomas R  Petersen Gloria  Riboli Elio  Salanti Georgia  Seminara Daniela  Smeeth Liam  Taioli Emanuela  Timpson Nic  Uitterlinden Andre G  Vineis Paolo  Wareham Nick  Winn Deborah M  Zimmern Ron
Affiliation:Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina 45110, Greece. jioannid@cc.uoi.gr
Abstract:
Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases. A Network of Investigator Networks has been set up to drive the process, sponsored by the Human Genome Epidemiology Network. A workshop is planned to develop consensus guidelines for reporting results of genetic association studies. Published literature databases will be integrated, and unpublished data, including 'negative' studies, will be captured by online journals and through investigator networks. Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews.
Keywords:
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