ApoE4干扰大脑代谢诱发阿尔茨海默病

 阿尔茨海默病（AD）是导致老年人认知障碍的最主要疾病。AD也是主要的一种神经退行性疾病，其中约95%是晚发型AD（LOAD）。目前，LOAD的发病机制仍不清楚，但是，4型载脂蛋白E （ApoE ε4，ApoE4）是已知的最大风险基因。以临床及基础实验结果为证据，探讨了ApoE4导致大脑出现糖脂代谢异常及相关机制。AD患者早期脑内也有糖脂代谢的紊乱，且代谢紊乱进一步加重认知障碍。因此，ApoE导致大脑代谢紊乱，可能促进AD的发生发展。靶向ApoE4改善大脑代谢，可能是AD药物研发的新方向。

ApoE4 induces Alzheimer's disease through brain metabolic abnormalities

The Alzheimer's disease (AD), a neurodegenerative disease, is the major cause of dementia in senior people. The late-onset AD (LOAD) accounts for more than 95% of the total AD population. Apolipoprotein E ε4 (ApoE4) is the most prevalent risk gene in the LOAD. In this review, we discuss the mechanisms by which ApoE4 contributes to the alterations of the energy and the lipid metabolism. Alterations of metabolism, including the energy and the lipid, are frequently observed in the brains of individuals with a mild cognitive impairment and the AD. Therefore, ApoE4 induces the LOAD pathogenesis probably by impairing the metabolic homoestasis based on the clinical and basic researches. This could potentially provide new therapeutical targets in the drug development for the AD.